Computational Movement Disorders Lab

Quantitative human motor neuroscience across health and disease

We study human movement as a high-dimensional behavioural output of the nervous system. Our research combines quantitative movement tracking, wireless neurophysiology, and computational modelling to understand how motor control is organised, how coordination and variability emerge, and how these processes are altered in neurological disease.

A central goal of the lab is to develop rigorous, reproducible methods for measuring behaviour in naturalistic settings. By characterising the structure and variability of movement and relating these features to neural and physiological signals, we aim to build mechanistic accounts that link circuit-level function to observable action.

Movement disorders provide a powerful window into motor system function, offering well-defined perturbations of control and coordination. Insights from this work inform our understanding of disease mechanisms and support the development and evaluation of targeted neuromodulation and neurorehabilitation strategies.

We are an interdisciplinary group based at the Gatsby Computational Neuroscience Unit, with experimental work conducted in purpose-built human movement laboratories in the Department of Motor Neuroscience and Movement Disorders. Our research sits at the interface of human motor neuroscience, computational neuroscience, and experimental methods development, with a strong emphasis on open, reproducible tools and datasets that lower barriers to quantitative movement research and enable reuse across laboratories, disciplines, and settings.

news

Dec 19, 2025 🎉 Award win! Our work on scalable behavioural acquisition systems has been recognised with the Meta Reality Lab Motor Learning and Ethical Design Award, in collaboration with NeuroGEARS. Congratulations to Iván and Marta for a superb poster and presentation showcasing this work.
Dec 16, 2025 Upcoming conference: Neurophysiological Bases of Human Movement (16–17 December, King’s College London). Anna giving a talk on phenomenology in human movement disorders and debating black-box versus mechanistic modes of scientific discovery 📣
Dec 11, 2025 Looking forward to Advances in Motor Learning II (11–12 December, University of Birmingham). Mireia and Marta will present ‘Decoding rating scales in movement disorders’, Marta and Iván will update on Building scalable tech for behavioural sampling. Anna will deliver a keynote in the disorders section, discussing the development and application of scalable technologies in human movement science.
Jul 23, 2025 Congratulations to Kate on being awarded a prestigious NIHR Predoctoral Fellowship to advance research into the mechanistic basis of neurophysiotherapy interventions for dystonia.
May 23, 2025 :fast_forward: Thank you to the National Brain Appeal for awarding us an Innovation Fund to start developing scalable motion capture systems in collaboration with NeuroGEARS!
May 21, 2025 :fast_forward: Thank you to UCL Research Capital Investment Fund (RCIF) for their grant for further equipment in the lab!
Jan 08, 2025 A hot topic article for Movement Disorders showcasing scientific work by Smoulder et al. revealing a neural basis for choking under pressure. Informative for neurological disorders such as task-specific dystonia.
Jul 22, 2024 In a new paper in Nature Scientific Reports we discuss whether sensitive markers of dexterity could be biomarkers for different stages of task-specific dystonia.
Sep 08, 2023 Symposium on the Neuroscience of Expert Performance at the Royal College of Music, co-organised with Maria Herrojo Ruiz and Katja Kornysheva. Many thanks to the panel, RCM colleagues and our multidisciplinary audience. The event was made possible by outreach grants from the Guarantors of Brain and Goldsmiths, University of London.
Sep 01, 2023 New article with Mark Edwards debating significance of clinical phenotype and how circuit-level understanding is critical to optimise treatment strategies in patients: Between Nothing and Everything: Phenomenology in Movement Disorders